Showing posts with label SNP. Show all posts
Showing posts with label SNP. Show all posts

Saturday, December 13, 2025

A cliodynamic analysis of the SNP in Scotland

---

Cliodynamics and the Scottish Independence Movement


Another example of the power of the Cliodynamics framework of analysis. Peter Turchin’s structural-demographic theory frames political upheaval in terms of deep forces rather than personalities or contingencies. In this analysis, his model highlights three dynamics: mass immiseration, elite overproduction, and state fiscal fragility. The interplay of these trends shapes whether societies remain stable or veer into crisis. It is illuminating to apply this lens to the Scottish independence movement.

For decades, the SNP has functioned as a counter-elite organisation. Its leaders and activists are talented professionals - lawyers, academics, politicians - who, within the framework of the London-centric United Kingdom, are blocked from the very top tier of elite status. Prime ministerships, treasury posts, intelligence leadership, senior ambassadorships, and control over monetary policy are all reserved to Westminster. Scotland’s elites hold positions of influence, but the most prestigious and powerful roles remain off-limits.

Independence promises to change that. A sovereign Scotland would multiply elite slots: cabinet portfolios, a central bank and governorship, top civil-service and military posts, regulators, and ambassadorships abroad. In cliodynamic terms, secession would absorb part of the elite surplus by creating a fresh pyramid of offices. This explains the persistent drive of the SNP and its allies: they have the structural incentive to keep pushing.

The problem lies with the masses. For Turchin, immiseration (stagnant or declining wages and prospects) among ordinary people supplies the fuel for counter-elites. Yet here the calculus is difficult. Scotland benefits from fiscal transfers within the UK, allowing higher public spending than its domestic tax base can sustain. Independence would mean replicating expensive state functions, assuming a higher deficit, and facing uncertainty over currency and borrowing: classic diseconomies of scale. To many Scottish workers and pensioners, the subconscious message is simple: life could get poorer, not better.

This mismatch between elite incentives and mass fears was stark in 2014. The referendum mobilised nearly half the electorate in favour of independence - remarkable given establishment opposition - but economic anxiety kept the “Yes” vote below 50%. The counter-elites could not fully align immiseration with their project.

Since then, Brexit, austerity, and Conservative dominance at Westminster have supplied new grievances. The case for independence is reframed as a chance to escape England’s trajectory, to rejoin Europe, to build a fairer welfare state. The SNP hoped that deteriorating UK politics will tilt the cost–benefit calculation for ordinary Scots.

But cliodynamics suggests that unless the UK itself enters deeper crisis - fiscal breakdown, contested elections, or draconian repression - the Scottish masses remain a brake. Counter-elites cannot carry secession on their own; they require a perception that independence alleviates immiseration rather than worsens it.

In this sense, the independence movement is structurally-driven but contingently-blocked. It will not vanish, because the elite incentive remains. But it will not triumph unless London delivers the kind of trigger event that redefines the economic risks of secession. If that occurs, the Scottish counter-elites will be ready, and the new elite pyramid will rise quickly.


Why the SNP is scandal-ridden and out of ideas—and why Reform is rising in Scotland

Longevity breeds establishment. The SNP’s long incumbency since 2007 has generated fatigue and clientelism. Financial investigations, leadership turmoil, and factional splits have eroded moral authority. A counter-elite that captures regional power without delivering its promised rupture starts to look like the establishment it opposed.

Strategic exhaustion. With London refusing a fresh referendum, Brussels cautious, and the economic case unpersuasive, the SNP’s narrative has stalled. Counter-elites without a credible path to power appear hollow; policy improvisation reads as drift.

Reform’s counterintuitive traction. In Scotland, Reform functions as a protest vehicle rather than a cultural fit. Immiserated voters use it to punish an exhausted political class in Edinburgh as well as London. Some frustrated Scottish aspirants also pivot toward a UK-wide populist ladder that seems to be moving while the SNP’s hierarchy ossifies.

Cliodynamic synthesis. The SNP’s decay is what happens when a counter-elite movement cannot consummate elite circulation. Reform’s gains signal that discontent will find an outlet across national lines when domestic counter-elites are discredited. Unless structural conditions change - or Westminster triggers a crisis that flips mass risk-perception - the Scottish independence project will remain structurally-incentivised yet mass-constrained.

Saturday, January 30, 2016

SSC SNP picks


er, ... no ... .

I mentioned in my previous post that you could link a SNP (eg rs4570625) to your own 23andMe results using a link like this:
https://www.23andme.com/you/explorer/snp/?snp_name=rs4570625
Scott Alexander at the almost-always-reliable* Slate Star Codex wrote (November 2014) this amusing post "How To Use 23andMe Irresponsibly" describing his favourite SNPs.

Well, now they're my favourites too and I copy his (lightly edited) thoughts below, but with the SNP references switched from his choice - SNPedia - to my choice, 23andMe.

Quick reminder: most traits in life are quantitative, they come in degree, not kind. In the human genome they are polygenic - many SNPs are involved (and other genetic mechanisms too) .. so one SNP is hardly going to be decisive. In most cases.

--- How To Use 23andMe Irresponsibly - (from SSC)  ---
"rs909525 is linked to the so-called “warrior gene” which I blogged about in the last links roundup. People with the normal four or five repeat version of these gene are less violent than people with the three-repeat version, and people with the two-repeat version are massively overrepresented among violent criminals. ... Although this SNP isn’t the warrior gene itself, it’s linked to it closely enough to be a good predictor.

"This is on the X chromosome, so men will only have one copy (I wonder how much of the increased propensity to violence in men this explains). It’s also one of the minus strand ones, so it’ll be the reverse of what SNPedia is telling you. If you’ve got T, you’re normal. If you’ve got C, you’re a “warrior”. I’ve got C, which gives a pretty good upper limit on how much you should trust these SNPs, since I’m about the least violent person you’ll ever meet. But who knows? Maybe I’m just waiting to snap. Post something dumb about race or gender in the open thread one more time, I dare you…"

I'm T and my mother, Beryl Seel was (T;T), both .. normally unwarlike.

"rs53576 in the OXTR gene is related to the oxytocin receptor, which frequently gets good press as “the cuddle hormone” and “the trust hormone”. Unsurprisingly, the polymorphism is related to emotional warmth, gregariousness versus loneliness, and (intriguingly) ability to pick out conversations in noisy areas.

"23andMe reads this one off the plus strand, so your results should directly correspond to SNPedia’s – (G;G) means more empathy and sociability and is present in 50% of the population, anything else means less. I’m (A;G), which I guess explains my generally hateful and misanthropic outlook on life, plus why I can never hear anyone in crowded bars."

We're both (G;G) which makes us kind and empathic ... .

"rs4680 is in the COMT gene, which codes for catechol-o-methyltransferase, an enzyme that degrades various chemicals including dopamine. Riffing on the more famous “warrior gene”, somebody with a terrible sense of humor named this one the “worrier gene”.

"One version seems to produce more anxiety but slightly better memory and attention; the other version seems to produce calm and resiliency but with a little bit worse memory and attention. (A;A) is smart and anxious, (G;G) is dumb and calm, (A;G) is in between. if you check the SNPedia page, you can also find ten zillion studies on which drugs you are slightly more likely to become addicted to. ..."

Both of us are (A;G) which makes us average and average.

"rs7632287, also in the oxytocin receptor, has been completely proportionally and without any hype declared by the media to be “the divorce gene”. To be fair, this is based on some pretty good Swedish studies finding that women with a certain allele were more often to have reported “marital crisis with the threat of divorce” in the past year (p = 0.003, but the absolute numbers were only 11% of women with one allele vs. 16% of women with the other). This actually sort of checks out, since oxytocin is related to pair bonding. If I’m reading the article right (G;G) is lower divorce risk, (A;A) and (A;G) are higher – but this may only apply to women."

Both my mother and I are (A;G) which makes her a bit .. flighty?

"rs11174811 is in the AVPR1A gene, part of a receptor for a chemical called vasopressin which is very similar to oxytocin. In case you expected men to get away without a divorce gene, this site has been associated with spousal satisfaction in men. Although the paper is extremely cryptic, I think (A;A) or (A;C) means higher spousal satisfaction than (C;C). But if I’m wrong, no problem – another study got the opposite results."

I'm (C;C) as was my mother, Beryl Seel, which means .. probably nothing.

"rs25531 is on the serotonin transporter. It's Overhyped Media Name is “the orchid gene”, on the basis of a theory that children with one allele have higher variance – that is, if they have nice, happy childhoods with plenty of care and support they will bloom to become beautiful orchids, but if they have bad childhoods they will be completely screwed up. The other allele will do moderately well regardless. (T;T) is orchid, (C;C) is moderately fine no matter what. There are rumors going around that 23andMe screwed this one up and nearly everybody is listed as (C;C)."

For my mother and myself, 23andMe did not report on this one.

"rs1800955 is in DRD4, a dopamine receptor gene. It's overhyped media name is The Adventure Gene, and supposedly one allele means you’re much more attracted to novelty and adventure. And by “novelty and adventure”, they mean lots and lots of recreational drugs. This one has survived a meta-analytic review. (T;T) is normal, (C;C) is slightly more novelty seeking and prone to drug addiction."

I was not genotyped at this location and my mother, Beryl Seel was (C;T) which made her a little bit adventurous with lots of use of recreational sherry.

"rs2760118, in a gene producing an obscure enzyme called succinate semialdehyde dehydrogenase, is a nice polymorphism to have. According to this article, it makes you smarter and can be associated with up to fifteen years longer life (warning: impressive result means almost certain failure to replicate). (C;C) or (C;T) means you’re smarter and can expect to live longer; (T;T) better start looking at coffins sooner rather than later."

I'm (T;T) and my mother, Beryl Seel was (C;T) which makes me resigned to an early grave. She lived to 92.

"rs6311 is not going to let me blame the media for its particular form of hype. The official published scientific paper on it is called “The Secret Ingredient for Social Success of Young Males: A Functional Polymorphism in the 5HT2A Serotonin Receptor Gene”.

"Boys with (A;A) are less popular than those with (G;G), with (A;G) in between – the effect seems to be partly mediated by rule-breaking behavior, aggression, and number of female friends. Now it kind of looks to me like they’re just taking proxies for popularity here, but maybe that’s just what an (A;A) nerd like me would say. Anyway, at least I have some compensation – the popular (G;G) guys are 3.6x more likely to experience sexual side effects when taking SSRI antidepressants."

I'm (G;G) and my mother, Beryl Seel was (G;A) which makes me out to be some kind of bad boy!? I must remember to keep off those SSRI tablets.

"rs6265, known as Val66Met to its friends, is part of the important depression-linked BDNF system. It’s a bit depressing itself, in that it is linked to an ability not to become depressed when subjected to “persistent social defeat”. The majority of whites have (G;G) – the minority with (A;A) or (A;G) are harder to depress, but more introverted and worse at motor skills."

I predicted I would be (A;A) based on poor motor skills and in fact I'm (A;G). My mother, Beryl Seel was the normal (G;G) which is consistent with her not-bad motor skills (except at driving).

"rs41310927 is so cutting-edge it’s not even in SNPedia yet. But these people noticed that a certain version was heavily selected for in certain ethnic groups, especially Chinese, and tried to figure out what those ethnic groups had in common.

"The answer they came up with was “tonal languages”, so they tested to see if the gene improved ability to detect tones, and sure enough they claimed that in experiments people with a certain allele were better able to distinguish and understand them. Usual caveats apply, but if you want to believe, (G;G) is highest ability to differentiate tones, (A;A) is lowest ability to differentiate tones. (A;G) is in between.

Sure enough, I’m (A;A). All you people who tried to teach me Chinese tonology, I FRICKIN’ TOLD YOU ALL OF THE WORDS YOU WERE TELLING ME SOUNDED ALIKE."

Both of us test (A;G) so I'm sure we would have struggled with Mandarin, a daily requirement in Bristol.
So, just to reiterate, if you have a 23andMe account, click on the rs... links and see how you scored.

---

* If you care, I don't share his worries about the existential threat of the 'new AI'.

Friday, January 29, 2016

Linking a SNP (rs1234567) to your own 23andMe variant

You read about a new genetic discovery - some allele has some effect - and you wonder about yourself. Your genome (or at least the subset they sequenced) is catalogued in the 23andMe database and some sites let you check your own allele variant (SNP - 'snip') in just one click. How do they do that?

They use a link like this.
https://www.23andme.com/you/explorer/snp/?snp_name=rs4570625
Gene variants for schizophrenia are just in the news. Now in the current report the relevant risk factor is number of copies of the C4 gene, something which is not assessed by 23andMe at present. But SNPs do have some predictive power for schizophrenia and other mental conditions - for example this (at Genetic Lifehacks):
rs4570625 – T is the minor allele and has been studied in reference to a number of psychiatric conditions. A recent study found that those carrying the T allele were more susceptible to major depression even when not exposed to “high-negative life events”.  A Chinese study in 2014 found that those with the T allele were more susceptible to paranoid schizophrenia.
When you click on the rs4570625 link above, you're taken to the 23andMe login page. After logging in, this is what you see (click on image to make larger):



I seem to be OK as regards that particular allele (one SNP is not going to make that much difference in what is a polygenic condition) - here's what SNPedia has to say about rs4570625 (for what it's worth).

Incidentally, I'm GG and my mother was GT. What can we say about my father? Well, I received one of those Gs from my mother, so I must have got the other from my father, so he was either GG or GT. Now, I didn't actually need my mother's sequence to deduce my father's options, but knowing she was GT means that the odds favour my father being GG.

---

In case you're wondering: what's with these rs1234567 things ...?
"A reference SNP ID number, or “rs” ID, is an identification tag assigned by NCBI to a group (or cluster) of SNPs that map to an identical location."

Saturday, May 09, 2015

Handling Nicola

In Scotland we have an anti-austerity party, the SNP, facing a central UK authority determined to clear the deficit. Remind you of anything?

Anti-austerity Syriza in Greece has a mandate to maintain and even increase public spending while its lack of revenues and overarching debts makes this impossible. The European Union is not inclined to continue paying the difference indefinitely. When will this particular can cease being kicked up the road?

Nicola Sturgeon, the SNP leader, will say that Scotland has voted decisively against austerity and that the Scots will not accept any cuts in public spending, especially on welfare. The UK Government will reply that if the Scots were an independent country, their current spending plans would generate an 8% deficit on Scotland's already large share of the public debt and are therefore unaffordable.

How to proceed?

It is tempting to let Scotland see the error of its ways. If it was responsible for raising its own taxes to cover its spending plans, surely the mismatch would be obvious? But the SNP would simply cover the gap by borrowing, as Syriza has done. The deficit would rise (i.e. the public debt would carry on increasing) but Scotland would claim it was 'borrowing to invest' or that repayments would be 'easier down the road' when the economy improved.

It is rarely difficult to find plausible arguments for maxing out the credit card.

If Scotland were an independent state, the markets would respond to repayment worries by increasing interest rates. But Scotland uses the pound sterling and, as part of the UK, its debts are guaranteed by the British state. So there is no downside for the Scottish government to carry on borrowing - it's a form of moral blackmail over the rest of the UK (primarily the English). If the UK Government tries to put a limit to how much the Scots can borrow, the SNP will claim English interference and imperialism and call for the shackles to be released and full independence.

Truly there are no half-way houses between unity and independence if the latter is what you're determined upon. If there were, the Greek situation would have been sorted out long since.

Enjoy your victory, Mr Cameron.