The last shuttle goes up on Friday of this week. After that, no more manned flights on US platforms for an indefinite period. But really, where is there to go?
The Economist argued in its most recent edition (July 2nd) that we have at last reached the end of the space-age, defined as exploration, manned or otherwise, outside of geosynchronous orbit.
At sciencefiction.com I found it hard to disagree.